Terpenes - are found in all plants, are common constituents of flavorings and fragrances**. Terpenes are responsible for the aroma of Cannabis. The FDA has generally recognized Terpenes as “safe.” Terpenes act on receptors and neurotransmitters. Terpenes may act as serotonin uptake inhibitors (like antidepressants like Prozac), which enhance norepinephrine activity (similar to tricyclic antidepressants such as Elavil); they may increase dopamine activity; and they can augment GABA (the “downer” neurotransmitter that counters glutamate, which is the “upper”). Much more specific research is needed for improved accuracy in describing and predicting how terpenes in cannabis can be used medicinally to help treat specific ailments. Terpenes are still not evidence-based pharmacogenetically; therefore, not included in PGX test.